NLR proteins and parasitic disease

Pyrin- and CARD-only Proteins as Regulators of NLR Functions

Upon activation Nod-like receptors (NLRs) assemble into multi-protein complexes such as the NODosome and inflammasome. This process relies upon homo domain interactions between the structurally related Pyrin and caspase-recruitment (CARD) domains and adaptor proteins, such as ASC, or effector proteins, such as caspase-1. Although a variety of NLRP and NLRC complexes have been described along wi...

The “sensor domains” of plant NLR proteins: more than decoys?

A commentary on A novel conserved mechanism for plant NLR protein pairs: the " integrated decoy " hypothesis Our conceptual and mechanistic understanding of how plant nucleotide-binding leucine-rich repeat (NLR or NB-LRR) proteins perceive pathogens continues to advance. NLRs are intracel-lular multidomain proteins that recognize pathogen-derived effectors either directly or indirectly In the d...

TLR, NLR and other modulators as infectious disease vaccine adjuvants

Vaccines based on attenuated or killed viruses and bacteria are highly effective in preventing infection with a range of pathogens, but can have safety issues. Therefore, there is a move towards subunit vaccines based on recombinant proteins or naked DNA. However, protein subunit vaccines are typically poorly immunogenic when administered alone and therefore require co-administration with adjuv...

Regulation of the antimicrobial response by NLR proteins.

Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate immune receptors that play a pivotal role in microbial sensing, leading to the initiation of antimicrobial immune responses. Dysregulation of the function of multiple NLR family members has been linked, both in mice and humans, to a propensity for infection and autoinflammatory disease. Despite ...

Distribution List Bas VAN DOORN NLR ( NLR )